Ipratopium Bromide And Levosalbutamol Inhaler
|Form||200 metered doses|
|Application||Clinic, Personal, Hospital|
DUOLIN Inhaler Is a combination of ipratropium bromide and levosalbutamol tartarate.
Ipratropium bromide is an anticholinergic (parasympatholytic) agent, which inhibits vagally-mediated reflexes by antagonizing the action of acetylcholine, the transmitter agent released from the vagus nerve.
Levosalbutamol tartarate is a relatively selective beta2-adrenergic agonist, whose activation leads to an increase in intracellular adenyl cyclase, the enzyme which catalyses the conversion of adenosine triphosphate (ATP) to cyclic-3', 5'- adenosine monophosphate (cAMP).
Activation of beta2-adrenergic receptors on airways smooth muscle leads to the activation of adenylate cyclase and to an increase in the intracellular concentration of cAMP. The increase in cAMP is associated with the activation of protein kinase A, which in turn, inhibits the phosphorylation of myosin and lowers intracellular ionic calcium concentrations, resulting in muscle relaxation.
Levosalbutamol relaxes the smooth muscles of all airways, from the trachea to the terminal bronchioles. Increased cAMP concentrations are also associated with the inhibition of the release of mediators from mast cells in the airways. Levosalbutamol acts as a functional antagonist to relax the airways, irrespective of the spasmogen involved, thus protecting against all bronchoconstrictor challenges. While it is recognized that beta2-adrenergic receptors are the predominant receptors on bronchial smooth muscle, data indicate that there are beta-receptors in the human heart, 10-50% of which are beta2-adrenergic receptors. The precise function of these receptors has not been established.
However, all beta-adrenergic agonist drugs can produce significant cardiovascular effects in some patients, as measured by pulse rate, blood pressure, symptoms, and/or electrocardiographic changes.
Ipratropium bromide is an anticholinergic (parasympatholytic) agent, which appears to inhibit vagally-mediated reflexes by antagonizing the action of acetylcholine, the transmitter agent released at neuromuscular junctions in the lungs. Anticholinergics prevent increases in intracellular concentration of cyclic guanosine monophosphate (cGMP), which are caused by interaction of acetylcholine with the muscarinic receptor on bronchial smooth muscle.
0.5 MG Budecort Respules
|Packaging Size||8 x 5 x 2 ml|
|Composition||Each 2 ml contains Budesonide IP...... 0.5 mg|
|Grade Standard||Medicine Grade|
|Packaging Size||120 metered doses|
Minimum Order Quantity: 10 Piece
|Packaging Size||120 metered doses|
Before taking it, you should tell your doctor if you have any kidney or liver diseases so that your doctor can prescribe a suitable dose for you. You should also tell your doctor if you are pregnant, planning pregnancy or breastfeeding.
Foracort Inhaler 200 is a combination of two medicines in one inhaler. It relieves the long-term symptoms of asthma and COPD, making breathing easier. It works by inhibiting the release of certain chemical messengers that cause inflammation (swelling) and relaxes the muscles in the airways.
Your doctor will tell you how often you need to use your inhaler. The effect of this medicine may be noticeable after a few days but will only reach its maximum after a few weeks. This medicine must be used regularly to be effective, so go on taking it even if you don't have any symptoms. That means it’s doing its job. If you stop taking it your symptoms may get worse. This medicine should not be used to relieve sudden shortness of breath. If sudden shortness of breath occurs, use your rescue inhaler. To get the benefit from this medicine you need to make sure you get your inhaler technique right, otherwise, it does not work as well.
The most common side effects are nausea, vomiting, respiratory tract infection, hoarseness of voice, fungal infections in the mouth, cough, headache, sore throat, musculoskeletal (bone, muscle or joint) pain, and increased heart rate. If you get there, don’t stop taking it but do talk to your doctor. You can prevent some of these symptoms by rinsing your mouth and throat with water or brushing your teeth after using your inhaler. There are other, rarer side effects which can be serious. Talk to your doctor if you're worried about them.
Flomist Nasal Spray
|Packaging Size||10 ml|
|Dose||100 metered doses|